Mina OKOCHI, Ph.D

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Professor
O-okayama Campus, South 1, room 311
TEL & FAX +81-3-5734-2116

e-mail:

Okochi Lab.

Research Fields

Biotechnology, Biochemical Engineering, Nanotechnology, Peptide Engineering, Bioelectronics

Research Topics

Recent advancement in biotechnology and nanotechnology has explored and developed the interdisciplinary area of nanobio-engineering which can be applied for systematic analysis of biological phenomena. Since biological reaction progresses through the interaction of various molecules in a cell, the investigation of these dynamics would be important to control the cellular function. One considerable interest of the functional ligands is peptide. In the group of M. Okochi, peptides are focused on the analysis of molecular interaction using a fabricated peptide array. Peptide, the molecule consisting of two or more amino acids with molecular weight below 10,000 Da, is one of the significant molecules that can regulate the complex biological function of our body. These peptides have attracted attention in the fields of pharmaceutics, biomedicals, diagnostics, functional foods, as well as nano-functional materials. Our challenge is to construct biosensing system for systematic analysis of biomolecular recognition by integrating material science, nanotechnology and bioelectronics.

  • IgE epitope analysis for evaluation and prediction of food allergy outgrow
  • Design of functional peptides
  • Development of bioanalysis system using magnetic beads
  • Electrochemical sterilization water and control of biofouling

    • Education

    Ph.D. in Biotechnology, Tokyo University of Agriculture and Technology, 1998

    M.S. in Biotechnology, Tokyo University of Agriculture and Technology, 1995

    B.S. in Biotechnology, Tokyo University of Agriculture and Technology, 1993

    Previous Positions

    2014.4 – Present Professor, Department of Chemical Engineering, Tokyo Institute of Technology

    2008.4 – 2014.3 Associate Professor, Department of Biotechnology, Nagoya University

    2004.10 – 2008.3 Lecture, Department of Biotechnology, Nagoya University

    1999.9 – 2004.9 Assistant Professor, Department of Biotechnology, Tokyo University of Agriculture and Technology

    1998.4 – 1999.9 Research Fellow, Japan Society for Promotion of Science, Tokyo University of Agriculture and Technology

    1999.3 – 1999.7 Research Fellow (British Council Fellow), Heriot-Watt University

    Awards

    Encouragement Award of the Society for Biotechnology, Japan (Saito Award) in 2012
    “Application and development of technologies for cell analysis using magnetic nanoparticles”

    Excellent paper Award of Journal of Chemical Engineering of Japan in 2009
    H Kiode et al. Preparation of L929 cell array by magnetic cell labeling method with unmodified colloidal magnetite nanoparticles for single cell detection of cell response induced by TNF-a. 42(4) 290-297 (2009).

    Academic Award of the Tokai Chemical Industry Association in 2007
    “Screening of low molecular weight peptides that mimic TRAIL”

     Recent Publication

  • Masashi Kuboyama Ryuji Kato, Mina Okochi, Hiroyuki Honda (2012) Screening for silver nanoparticle-binding peptides by using a peptide array. Biochem. Eng. J. 66:73-77
  • Yuji Asai, Tomoya Sugita, Ryuji Kato, Mina Okochi, Kyuya Nakagawa, Hiroyuki Honda (2012) Enhancement of the activity of a Lactobacilli-aggregating by freezing treatment. Jpn. Chem. Eng. J. 48:609-614.
  • Kei Kanie, Yuji Narita, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Tomohiko Yoshioka, Mina Okochi, Hiroyuki Honda, Ryuji Kato (2012) Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells. Biotechnol. Bioeng. 109: 1808-1816.
  • Takashi Ochiai, Tomoya Sugita, Ryuji Kato, Mina Okochi, Hiroyuki Honda (2012) Screening of an alpha-amylase inhibitor peptide by photolinker-peptide array. Biosci. Biotechnol. Biochem. 76:819-824.
  • Mina Okochi, Taku Matsumura, Shuhei Yamamoto, Eiichi Nakayama, Kowichi Jimbow, Hiroyuki Honda (2013) Cell behavior observation and gene expression analysis of melanoma associated with stromal fibroblasts in a three-dimensional magnetic cell culture array. Biotechnol. Prog. 29, 135-142.
  • Mina Okochi, Taku Matsumura, and Hiroyuki Honda (2013) Magnetic force-based cell patterning for evaluation of the effect of stromal fibroblasts on invasive capacity in 3D cultures. Biosens Bioelectron 42, 300-307.
  • Masahiro Nakatochi, Makoto Katayama, Ryuji Kato, Mina Okochi, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Hiroyuki Honda (2013) Comprehensive combination analysis for screening of significant peptide epitopes using a slide glass type-exclusive peptide array from milk protein. Kagaku Kogaku Ronbunshu, 39:40-45.
  • Tomoya Sugita, Makoto Katayama, Mina Okochi, Ryuji Kato, Takamitsu Ichihara, Hiroyuki Honda (2013) Screening of peptide ligands that bind to the Fc region of IgG using peptide array and its application to affinity purification of antibody. Biochem. Eng. J. 79: 33– 40.

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